• evs.nci.nih.gov

    Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations.

  • raw_data/drugs_map.psv at master · HealthHack2015/raw_data ...

    Intranasal and parenteral formulations may be used to manage spontaneous or trauma-induced bleeds (e.g. hemarthrosis, intramuscular hematoma, mucosal bleeding) in patients with hemophilia A or von Willebrand's disease Type I. May also be used parenterally to prevent or treat bleeding in patients with uremia. |Antidiuretic Agents

  • Prodrug Designing of NSAIDs - academia.edu

    The carrier drug may with ethyl esters of aminoacids glycine, L-phenylalanine, L- be useful to overcome some side effects of the parent drug as tryptophan, L-valine, L-isoleucine, L-alanine, L-leucine, L- well. glutamic acid, L-aspartic acid and -alanine.

  • Magnesium hydroxide CAS#: 1309-42-8

    Magnesium hydroxide is a kind of non-absorption of antacid. This kind of drugs is not absorbed at all or only absorbed of a small amount by the digestive tract, thus having no systemic effects. Magnesium hydroxide has an effect similar to that of magnesium oxide. Its reaction with hydrochloric acid is slow and lasting effect.

  • Vitamin C - Health Benefits | Side Effects - Earth Clinic®

    Vitamin C Side Effects. Vitamin C is a water soluble vitamin, which means that it is not stored in the body like vitamin D, a fat soluble vitamin. When you give your body more vitamin C than it can use, it will flush out the rest through the bowel. Too much vitamin C will give you loose stools.

  • Citicoline: Uses, Side Effects, Interactions ... - webmd.com

    Side Effects & Safety Citicoline is POSSIBLY SAFE when taken by mouth short-term (up to 90 days). The safety of long-term use is not known. Most people who take citicoline don't experience ...

  • CN101972248B - Famotidine composition for injection and ...

    The invention relates to a famotidine composition for injection. The famotidine composition comprises famotidine and L-aspartic acid; and the preparation method of the composition comprises the following steps of: 1) preparing: placing the famotidine and the L-aspartic acid in a preparation tank in a weight proportion of 1 to 0.4, filling injection water, stirring to completely dissolve the ...

  • evs.nci.nih.gov

    A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. The agent also induces apoptosis in tumor cells.

  • WO1997008145A1 - Meta-guanidine, urea, thiourea or azacyclic ...

    N-t-Boc-L-aspartic acid, β-benzyl ester (75 g, 20 mmol) was dissolved in THF (30 ml) and added dropwise over a period of 30 minutes to BH 3-THF (400 ml, 40 mmol) at 0°C under a N 2 atmosphere. After the solution was stirred for 2.5 hours at 0°C, the reaction was quenched with 10% acetic acid in MeOH (50 ml), and the solvent was evaporated.

  • L-Valine - an overview | ScienceDirect Topics

    The same approach was implemented with another protecting group on an amino acid moiety and, valacyclovir was prepared by reaction of N-(Boc)-L-valine with acyclovir using 1-(3-dimethyl-aminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) as coupling agent and HCl in the deprotection step [160].

  • CancerTreatmentConventionalITO13-1 - DocShare.tips

    L-ASN to L-aspartic acid and ammonia, significantly depleting the circulating asparagines from plasma [27,121]. The most common side effect is related to inhibition of protein synthesis and allergic reactions. Hypersensitivity reactions can be solved by use of modified versions of L-ASNase such as

  • Peptide drugs – New Drug Approvals

    Common side effects of Cablivi reported by patients in clinical trials were bleeding of the nose or gums and headache. The prescribing information for Cablivi includes a warning to advise health care providers and patients about the risk of severe bleeding.

  • Amino Acids Supplements & Products - Herbal Remedies

    L-Proline is an amino acid that is essential for the synthesis of collagen, the most abundant protein in mammals. Collagen is the main structural protein that constitutes all human connective tissues, including skin, tendons, ligaments, joints, bone, and vasculature (veins and arteries).

  • Possible irritant/harmful effects to skin, eyes, and respiratory system. A new adjuvant product which is reported to have lower toxicity/side effects than traditional agents (e.g. CFA). Possible carcinogenic properties - attached product indicates that elevated animal occurrence of carcinoma may not be relatable to humans. FDA pregnancy category B.

  • NEW DRUGS – Page 2 – New Drug Approvals

    The standard therapy of pegylated- interferon and ribavirin induces serious side effects and provides viral eradication in less than 50% of patients. Combination therapy of HCV including ribavirin and interferonare currently is the approved therapy for HCV.

  • L-Carnitine: Uses, Side Effects, Interactions, Dosage, and ...

    Side Effects & Safety L-carnitine is LIKELY SAFE when taken by mouth for up to 12 months, and when used as an injection, with the approval of a healthcare provider. It can cause side effects such ...

  • pharmaceutics Flashcards | Quizlet

    Soluble in water to achieve adequate concentrations in aqueous phase of a system that has 2 or more phases, Prevents growth of microorganisms that are most likely to cause contamination, Concentration should not adversely affect patient health, Stable enough to maintain its concentration and chemical integrity throughout the shelf-life of the product, Should be compatible with other ...

  • Oral colon targeted delivery systems for treatment of ...

    Targeted drug delivery to the colon would therefore, ensure direct treatment at the disease site and, consequently, lower dosing and reducing systemic side effects. A variety of approaches have been used and systems have been developed for the purpose of achieving colonic targeting. One of the most common approaches is the prodrugs.

  • Cas Amino Acids And Wholesale, Amino Acid Suppliers - Alibaba

    Alibaba.com offers 70,120 cas amino acids and products. About 81% of these are vitamins, amino acids and coenzymes, 18% are auxiliaries and other medicinal chemicals, and 1% are sports supplements.

  • Crystallization and preliminary crystallographic studies of a ...

    Crystallization and preliminary crystallographic studies of a new L-asparaginase encoded by the Escherichia coli genome ... the molecular mechanisms of its anticancer activity and the side effects ...

  • Benefits and Advantages of Pasuchaca - falcon18.com

    The main attribute of Pasuchaca is antidiabetic in nature, purifier of blood and has hypoglycemic nature. It is often used as an astringent, combating diseases like chronic diarrhea, bleeding in cholera infantum and inflammation of ulcers located in the throat and the mouth.

  • AN-AZ - Bioactive Small Molecule Alphabetical Index | Sigma ...

    The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC 50 value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.

  • cdn.ymaws.com

    It has been used to treat several neurological disorders, including Lambert-Eaton myasthenic syndrome, multiple sclerosis, and Alzheimer's disease. It also has been used to reverse the effects of nondepolarizing muscle relaxants. At doses reported in the literature, the side effects of 4-AP for most patients do not appear to be serious.

  • Dataset - DrugBank Drug Targets - Ma'ayan Laboratory

    A carboxylic ester obtained by formal condensation of the carboxy group of azilsartan with the hydroxy group of 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one. A prodrug for azilsartan, it is used for treatment of hypertension. Demecarium: Lovastatin: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic ...

  • Prodrugs of NSAIDs: A Review

    The ten prodrugs of ketorolac were synthesized by reaction with ethyl esters of amino acids. The amino acids selected were glycine, L-phenylalanine, L-tryptophan, L-valine, L-isoleucine, L-alanine, L-leucine, L-glutamic acid, L-aspartic acid and β-alanine (Fig. 72) . The prodrugs were screened for pharmacological studies and ulcerogenic studies.

  • Prodrugs of NSAIDs: A Review ~ Fulltext - Bentham Open

    The nine alkyl ester prodrugs (Fig. 63) of flurbiprofen synthesized with an aim to reduce its gastrointestinal side-effects [54 Mohan, R.; Ramaa, C.S. Ester prodrugs of flurbiprofen: Synthesis, plasma hydrolysis and gastrointestinal toxicity. Indian J. Chem., 2007, 46B, 1164-1168.]. These were subjected to plasma hydrolysis and gastrointestinal ...

  • [PDF] Catalog - Free Download PDF - slidemy.com

    supportiveeffects,especiallywithregardto integrity of cellular membranes. Slippery elm is PM packet with your evening meal. Follow this

  • Incorporation of (2S,3S) and (2S,3R) β-Methyl aspartic acid ...

    Incorporation of (2S,3S) and (2S,3R) β-Methyl aspartic acid into RGD-Containing peptides Article in Bioorganic & Medicinal Chemistry 10(10):3331-7 · November 2002 with 11 Reads How we measure ...

  • Felbamate | Drug Information, Uses, Side Effects, Chemistry ...

    Know about technical details of Felbamate like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com.

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